Advances in alzheimers disease related dementias research nia is the primary federal agency supporting and conducting alzheimers disease research the institute also supports much work on cognitive health and related dementias. Porphyromonas gingivalis the keystone pathogen in chronic periodontitis was identified in the brain of alzheimers disease patients toxic proteases from the bacterium called gingipains were also identified in the brain of alzheimers patients and levels correlated with tau and ubiquitin pathology oral p gingivalis infection in mice resulted in brain colonization and increased . Our top five advances in 2017 spotlight the substantial progress we have made toward conquering alzheimers and other neurodegenerative diseases diversity in the drug pipeline the addf has been committed to funding a range of innovative drug targets for alzheimers disease since the day we started back in 1998. Advances in the treatment of alzheimers disease philip d sloane md mph university of north carolina at chapel hill school of medicine chapel hill north carolina am fam physician. Alzheimers is a devastating disease robbing victims of their memories and the ability to care for themselves more than 55 million americans are currently living with the disease which is the most common form of dementia alzheimers has no cure and current medications offer only modest improvement
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