Heat shock proteins hsps are overexpressed in a wide range of human cancers and are implicated in tumor cell proliferation differentiation invasion metastasis death and recognition by the immune system we review the current status of the role of hsp expression in cancer with special emphasis . The heat shock proteins hsps induced by cell stress are expressed at high levels in a wide range of tumors and are closely associated with a poor prognosis and resistance to therapy. For example hsp60 hsp70 and hsp90 the most widely studied hsps refer to families of heat shock proteins on the order of 60 70 and 90 kilodaltons in size respectively the small 8 kilodalton protein ubiquitin which marks proteins for degradation also has features of a heat shock protein. Chester medical school highlights the importance of heat shock proteins hsps in cancer cells and how we might utilise them therapeutically heat shock proteins hsps were originally identified as heat inducible gene products that had a role in cell survival. Heat shock proteins hsps have been linked to the therapy of both cancer and inflammatory diseases approaches that utilize contrasting immune properties of these proteins it would appear that hsp family members hsp60 and hsp70 whether from external sources or induced locally during inflammation can be processed by antigen presenting cells and that hsp derived epitopes then activate
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