Introduction the first published description of using a recombinant virus to deliver vaccine antigens from another infectious agent was the vaccinia virus recombinant engineered to express hepatitis b surface antigen in animal cells which upon immunization in chimpanzees induced protective immune response against hepatitis b challenge since then numerous breakthroughs have been made in . Vaccinia viruses re engineered to express foreign genes are robust vectors for production of recombinant proteins vaccinia viruses have been engineered to express immunizing antigens of herpesvirus hepatitis b rabies influenza human immunodeficiency virus hiv and other viruses figure 1 an electron micrograph of a vaccinia virus. There are no viral vector vaccines currently on market for use in humans there are twelve viral vector vaccines currently in use for veterinary diseases the approved vaccines include adenovirus fowlpox virus attenuated yellow fever yfv 17d and vaccinia virus vectors all of which are relevant as potential human viral vectored vaccines 1. Get this from a library vaccinia viruses as vectors for vaccine antigens proceedings of the workshop on vaccinia viruses as vectors for vaccine antigens held november 13 14 1984 in chevy chase maryland usa gerald v quinnan
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